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Under normal physiological conditions, the lias gene plays a key function in the synthesis of lipoic acid LIAS基因，也被称为LAS，全名是lipoic acid synthetase，中文名为脂酸合成酶。 这个基因位于我们的4号染色体上，具体来说是在4p14这个位置。 它是一个编码蛋白质的基因，意味着它会指导合成一种特定的蛋白质。 LIAS基因的主要功能是合成脂酸（lipoic acid），这是一种非常重要的辅酶，参与多种细胞代谢过程。 脂酸在细胞中扮演着“万能钥匙”的角色，能够帮助细胞进行能量代谢、抗氧化防御以及信号传导等多种功能。 因为这些功能，LIAS基因对维持细胞健康和正常生理功能至关重要。 尽管LIAS基因在正常生理过程中扮演着重要角色，但当这个基因出现问题时，可能会导致一些疾病。 目前，与LIAS基因相关的疾病主要包括： Lipoic acid is an important coenzyme that is involved in many important metabolic processes.
Lias (lipoic acid synthetase) is a protein coding gene LIAS的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为由该基因编码的蛋白质属于生物素和硫辛酸合成酶家族。 Diseases associated with lias include hyperglycinemia, lactic acidosis, and seizures and lipoic acid synthetase deficiency
Among its related pathways are metabolism of proteins and protein lipoylation.
上游是通过CRISPR-Cas9 功能缺失筛选找到了上游调节因子FDX1及LIAS，证明了铜死亡跟FDX1和蛋白脂酰化有关系。 然后提出了铜离子能结合脂酰化蛋白形成寡聚体，进而影响TCA循环。 这里面除了TCA循环，因为FDX1本身的功能，他们还提出FDX1还调控铁硫簇蛋白表达。 Welcome to the source code repository hosting software developments of the lias laboratory Software platforms and experimental prototypes associated with scientific publications are all provided to the scientific community under open source licenses. The biological target lias also known as lipoic acid synthase plays an important role in the synthesis of lipoic acid
Lias is an enzyme with a molecular mass of approximately 40 kda and it is present in many tissues showing high expression in liver and kidney. Meanings, etymology, pronunciation and more in the oxford english dictionary
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