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The key toxin of v In the recent study by jaskólska et al., an astonishing example of this sophisticated phenomenon was found in vibrio cholerae,with the pandemic strain encoding systems within two horizontally acquired pathogenicity islands that degrade incoming dna. Therefore, cholera phages in the environment, and their amplification in cholera patients remarkably influence the epidemiology of cholera, due mainly to phage mediated elimination of the causative epidemic strain.
Ctxφ infects some strains of vibrio cholerae, the bacterium that causes cholera Here, we identify a unique molecular battle between the classical biotype of vibrio cholerae and virulent phages icp1, icp2, and icp3 It carries the genes for cholera toxin (ctx), which makes cholera especially virulent
It can carry genes from one v
A new study shows that a virulent lineage of cholera acquired multiple distinct bacterial immune systems that have protected it from diverse types of phages This defense may have contributed to the massive scale of the latin american epidemic. Hypermutation provides a means for pathogens to escape phage predation within patients at the probable cost of accumulating deleterious mutations. So why are certain cholera strains so successful at evading phage attacks
Could this either enable or enhance the pathogen's devastating effect on human populations? As a prophage integrated into the genome, ctxφ encodes the cholera toxin (ct) that, when endocytosed by cells of the intestinal epithelium, leads to the profuse watery diarrhea for which cholera is infamous.
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