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Recently celebrating its 25th anniversary, the newport beach film festival is one of the largest luxury lifestyle film festivals in the united states This article explores the biochemical and biological properties of different fgfs, elucidating their roles in various biological processes. The event brings an internationally curated collection of films and vibrant cultural gatherings to the beautiful southern california coast.
A graphic showing the signaling pathways activated by fgf family proteins, the receptor binding specificities for each fgf ligand, and their suggested functions. This includes fgf types, fgfr activation, downstream pathways and therapies. Fibroblast growth factors (fgfs) are potent regulators of cell proliferation and differentiation
They are critically important in normal development, tissue maintenance, wound repair, and angiogenesis in somatic stem cells.
The mammalian fgf family contains 22 genes, 18 of which encode molecules known to signal through fgf tyrosine kinase receptors (table 1 (a)) The secreted signaling fgfs can be grouped into subfamilies based on biochemical function, sequence similarities, and evolutionary relationships. Like other fgf family members, basic fibroblast growth factor possesses broad mitogenic and cell survival activities, and is involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. Fgf function varies depending on the type of receptor engaged as well as target cell location and phenotype
The chart below lists the known receptors, target cells, and functions of each member of the fgf family. Explore how fgf signaling regulates cell growth, development and repair
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