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CCL5，CC类趋化因子配体5，也称为调节激活正常T细胞表达分泌因子（RANTES），是一种能使白细胞作定向移动的小分子分泌蛋白。 本文将详细介绍CCL5基因的意义和作用，包括其位置、功能、别名以及在生物医学中的重要性。 Ccl5 belongs to the cc subfamily of chemokines, due to its adjacent cysteines near n terminus
It is an 8kda protein acting as a classical chemotactic cytokine or chemokine. Therefore, in this review, we summarize the latest information on the origin, structure, and characterization of ccl5 and role of ccl5 in the tumor microenvironment. Diseases associated with ccl5 include human immunodeficiency virus type 1 and periapical granuloma.
Ccl5, also known as rantes (regulation of activation, expression and secretion by normal t cells), belongs to the cc subfamily of chemokines
CCL5 及其受体是肿瘤微环境重要成分，通过与 CCR5 结合促肿瘤发展。 文章梳理了 CCL5 的起源、结构等，还阐述其在乳腺癌、肺癌和卵巢癌中细胞间通讯机制，为肿瘤诊疗提供新思路。 We discovered that ccl5 has distinct expression patterns and a diagnostic biomarker significance in cancer. 本文将详细介绍CCL5基因的功能与作用机制，包括其生物学功能、信号传导通路、在免疫系统中的作用以及与多种疾病的关系。 CCL5全称为C-C基序趋化因子配体5，又称RANTES（调节激活正常T细胞表达和分泌因子），是免疫系统重要的信号分子。 CCL5主要由T淋巴细胞、血小板和某些上皮细胞分泌，能够招募单核细胞、嗜酸性粒细胞等免疫细胞向炎症部位聚集。
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